A Practical Guide to the Histology of the Mouse by Cheryl L. Scudamore

By Cheryl L. Scudamore

A sensible consultant to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse versions of sickness are used generally in biomedical learn with many thousands of recent versions being generated every year. entire phenotypic research of all of those types can make the most of histologic overview of the tissues.

This ebook is geared toward veterinary and scientific pathologists who're unusual with mouse tissues and scientists who desire to evaluation their very own mouse versions. It presents sensible tips at the assortment, sampling and research of mouse tissue samples for you to maximize the data that may be received from those tissues. in addition to illustrating the conventional microscopic anatomy of the mouse, the ebook additionally describes and explains the typical anatomic adaptations, artefacts linked to tissue assortment and history lesions to aid the scientist to tell apart those adjustments from experimentally- prompted lesions.

This could be a necessary bench-side better half for researchers and practitioners trying to find an available and well-illustrated consultant to mouse pathology.

  • Written via skilled pathologists and in particular adapted to the desires of scientists and histologists
  • Full color throughout
  • Provides suggestion on sampling tissues, necropsy and recording data
  • Includes universal anatomic adaptations, historical past lesions and artefacts that allows you to support non-experts comprehend even if histologic diversifications obvious are a part of the conventional history or on the topic of their experimental manipulation

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Additional resources for A Practical Guide to the Histology of the Mouse

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Dintzis), Elsevier, Amsterdam, pp. 339–394. A. (2000) Chemical fixation, in Principles and Techniques of Electron Microscopy. Biological Applications (ed. A. Hayat), 4th edn. Cambridge University Press, Cambridge, pp. 63–73. Hoff, J. (2000) Methods of blood collection in the mouse. Lab Animal 29, 47–53. , Morawietz, G. et al. (2004) Revised guides for organ sampling and trimming in rats and mice – Part 2. A joint publication of the RITA and NACAD groups. Experimental and Toxicologic Pathology 55, 413–431.

2 Anatomical land mark descriptors. (a) Cranial view of a mouse. (b) Caudal view of a mouse. (c) Lateral view of mouse. (d) Standing mouse. variation and common spontaneous pathology (Taylor 2011). It is important that these background changes are recognized and understood so that they are not misinterpreted as experimental or treatment-related changes (Schofield et al. 2012) particularly when encountered for the first time by scientists. Systematic recording of these background changes is also important to build up background data on the normal extent of variation within a strain or colony and to ensure that mouse phenotypes that result in alterations in the nature or incidence or severity of these changes are recognized.

Et al. (2010) A comparison of fixation methods on lung morphology in a murine model of emphysema. American Journal of Physiology: Lung Cellular and Molecular Physiology 299, L843–851. M. et al. (2012) Assessing cervical dislocation as a humane euthanasia method in mice. Journal of the American Association for Laboratory Animal Science 51, 352–356. A. (2000) The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene 19, 968–988.

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