Antihypertensive Agents by Edward L. Engelhardt (Eds.)

By Edward L. Engelhardt (Eds.)

content material: [Beta]-adrenoceptor antagonists as antihypertensive brokers / Richard Clarkson --
Centrally performing antihypertensive brokers / Wolfgang Hoefke --
Antihypertensives performing by way of a peripheral mechanism / John E. Francis --
Antihypertensive brokers as noticeable by way of the clinician / Gaddo Onesti.

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Increasing the dose causes a more d i s t i n c t r i s e i n blood pressure which might even conceal the hypotensive a c t i v i t y . Hyperten­ sive and hypotensive actions are accompanied by brady­ cardia. The n i c t i t a t i n g membrane i s contracted depen­ ding on the dose. The c a r o t i d sinus r e f l e x produced by clamping both common c a r o t i d a r t e r i e s causes an i n ­ crease i n blood pressure brought about by the decrease in pressure within the region of the c a r o t i d sinus.

A . van ZWIETEN: J. Pharm. Pharmacol. P. BARRETT and L. PROCITA: J. P h a r m a c o l . E x p e r . T h e r a p . 1970, 175, 593 HOEFKE, W. and W. KOBINGER: A r z n e i m i t t e l f o r s c h u n g 1966, 16, 1038 KOBINGER, W. and W. HOEFKE: i n "Hochdrucktherapie" e d . J. F. P F E I F FER, 4 Thieme, S t u t t g a r t 1968 KOBINGER, W. and A . : in " C l o n i d i n in d e r Augenheilkunde" B ü c h e r e i des A u g e n a r z t e s , B e i h e f t d e r klin. Monatsblätter f ü r Augenheilkunde 1974 63 4 KOBINGER, W .

ACS Symposium Series; American Chemical Society: Washington, DC, 1976. 2. HOEFKE Centrally Acting Antihypertensive Agents 33 provide the answer. The c e r v i c a l part of the medulla was cut and thereby the brain function of these animals was eliminated. I f the s i t e of action i s located i n the brain, neither a f a l l i n blood pressure nor bradycardia w i l l occur a f t e r s p i n a l i z a t i o n and t h i s i s a c t u a l l y what happened a f t e r administration of clonidine ( f i g .

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