By Eric M. Isselbacher (auth.), Kim A. Eagle MD, Ragavendra R. Baliga MD, MBA, Eric M. Isselbacher MD, Christoph A. Nienaber MD (eds.)
Aortic dissection impacts nearly in 10000 members and will be deadly. This state of the art book is as a result the mixed efforts of members from the International Registry of Aortic Dissection (IRAD). The publication has been divided into sections. every one bankruptcy offers a succinct evaluation of the present scientific literature and accommodates illustrations for extra explanation.
Ragavendra R. Baliga, MD, MBA is Director, element of Cardiovascular drugs and scientific Professor of inner medication, Ohio nation college health center East, Columbus, Ohio.
Christoph A. Nienaber, MD is Head, department of Cardiology, collage health facility Rostock, Rostock, Germany.
Eric M. Isselbacher, MD is Co-Director, Thoracic Aortic heart, Massachusetts common health center, Boston, Massachusetts.
Kim A. Eagle, MD, is an Albion Walter Hewlett Professor of inner drugs, leader of scientific Cardiology, and medical Director, Cardiovascular heart, college of Michigan healthiness method, Ann Arbor, Michigan.
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Extra info for Aortic Dissection and Related Syndromes
Aortic involvement is seen primarily in autosomal dominant EDS type IV33 . ANNULOAORTIC ECTASIA AND FAMILIAL AORTIC DISSECTION More than ﬁve mutations in the FBN-1 gene have now been identiﬁed in patients presenting with either sporadic or familial forms of thoracic aortic aneurysms and dissection34,35 . Histological examination of the aortic wall reveals elastolysis or loss of elastic ﬁbres, deposits of mucopolysaccharide-like materials, and cystic medial degeneration similar to Marfan’s syndrome.
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Baliga et al. 1). Aortic dissection is the most common catastrophe of the aorta, two to three times more common than rupture of the abdominal aorta. When left untreated, about 33% of patients die within the ﬁrst 24 hours, and 50% die within 48 hours. The two-week mortality rate approaches 75% in patients with undiagnosed ascending aortic dissection. Untreated, aortic dissection has a mortality rate of over 1% per hour. The diagnosis of aortic dissection is easily missed due to its variable clinical presentation, which mimics the involvement of various organ systems.