Applications of domino transformations in organic synthesis by Scott A., Prof. Snyder, Marco Bella, Alexander Dömling, Jon

By Scott A., Prof. Snyder, Marco Bella, Alexander Dömling, Jon Boyce, Gaelle Blond, Iain Coldham

The swift speed of evolution in domino, or cascade-based adjustments has revolutionized the perform of chemical synthesis for the construction of common items, designed molecules, and pharmaceuticals.


"Science of Synthesis: functions of Domino adjustments in natural Synthesis" explores the subject completely and systematically, serving because the foundation for useful functions and destiny examine. The 2-volume set provides the state-of-the-art when it comes to layout, approach, and experimental techniques, resulting in a number of occasions being complete inside a unmarried response vessel. The content material is prepared via the middle form of response used to start up the development, be it a pericyclic response, a metal-mediated transformation, radical chemistry, or an acid-induced cascade between many others.


Volume 2 covers pericyclic reactions (Diels-Alder, sigmatropic shifts, ene reactions), dearomatizations, and additions to C-O/C-N a number of bonds.

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Extra info for Applications of domino transformations in organic synthesis 2

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The non-isolable intermediate anthrone 24 was immediately oxidized in the next step. The complexity of the fragments in this example illustrates well the ability of Diels–Alder cascades to merge two late-stage intermediates. 5 mL) and cooled to 0 8C. 9 equiv) was added dropwise, and the soln immediately became bright yellow. 0 equiv) was added as a soln in THF (1 mL). The mixture slowly became a dark red-brown color, and, after 35 min, TLC indicated that no starting material remained. The intermediate anthrone 24 was used directly in the next step.

3 Michael/Henry Reactions . . . . . . . . . . . . . . . . . . . . . . . . . 4 Michael/Hemiacetalization Reactions . . . . . . . . . . . . . . . . . . . 3 Phosphoric Acid Catalyzed Domino Addition to C=O Bonds . . . . . . . . . 3 Lewis Acid Catalyzed Domino Addition to C=O Bonds . . . . . . . . . . . 4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

3 Phosphoric Acid Catalyzed Domino Addition to C=O Bonds . . . . . . . . . 3 Lewis Acid Catalyzed Domino Addition to C=O Bonds . . . . . . . . . . . 4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Additions to C=N Bonds and Nitriles E. Kroon, T. Zarganes Tzitzikas, C. G. Neochoritis, and A. 4 Additions to C=N Bonds and Nitriles . . . . . . . . . . . . . . . . . . . 1 Addition to C=N Bonds and the Pictet–Spengler Strategy .

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