By Lena Palaniyappan, Rajeev Krishnadas
Following the release of the recent syllabus and new MRCPsych examination via the Royal collage of Psychiatrists, this ebook includes greater than 450 a number of selection inquiries to aid psychiatry trainees to arrange for Paper 2 of the MRCPsych examination. assisting those MCQs are distinct explanatory solutions and revision notes, referenced to the main textbooks utilized by trainees.
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Additional info for Best of Five MCQs for MRCPsych Paper 2
The expression λ (lambda) refers to linkage disequilibrium. E. Second-degree relatives share 50% of their genes. 72. The proportion of phenotypic variation attributable to non-genetic causes among depressed patients is A. B. C. D. E. 30–40% 40–50% 90–95% 60–65% 10–20% 23 24 PSYCHIATRIC GENETICS | QUESTIONS 73. Which of the following is true regarding the APOE gene in Alzheimer’s disease? A. B. C. D. E. APOE e4 increases the risk of Alzheimer’s disease in a dose-dependent fashion. APOE e4 confers a protective effect against vascular dementia.
C. Heritability is the proportion of variation in a trait that can be attributed to genetic factors. It does not apply to a speciﬁc trait in an individual patient; it refers to the variation in the population as a whole. It is not immutable for a speciﬁc disease in a population; it will vary with the epidemiological changes in risk and environmental inﬂuences in a population, but it can be ﬁxed at a speciﬁc time and for a given set of circumstances. Heritability is related to the feasibility of ﬁnding a candidate gene for a disease or trait; if a disease has zero heritability in a population, there is no chance of ﬁnding a gene.
Psychiatric Genetics and Genomics. 119. 44. A. Allelic heterogeneity is said to be present if different alleles at the same locus produce the same trait or disease expression. Consider sickle cell disease. In this condition all affected individuals carry the same mutation at the same locus. This is called genetic homogeneity. But in cystic ﬁbrosis, at the same site on chromosome 7, 600 various mutations have been identiﬁed that result in the same disease phenotype. This is called allelic heterogeneity.