By A.V.S. & Julie Knight, Editors De Rueck
Chapter 1 Chairman's commencing comments (pages 1–2): Sir Alexander Haddow
Chapter 2 normal evaluate of the character of Differentiation (pages 3–17): M. Abercrombie
Chapter three unmarried phone Properties—Membrane improvement (pages 18–38): Murray D. Rosenberg
Chapter four Biochemical alterations in the course of Fertilization and Early Embryonic improvement (pages 39–64): J. Brachet
Chapter five Nuclear Transplantation and mobile Differentiation (pages 65–78): J. B. Gurdon
Chapter 6 reports at the suggestions law of Haemopoiesis (pages 79–100): Michael Feldman and Ilan Bleiberg
Chapter 7 attainable Mechanisms of the move of knowledge among Small teams of Cells (pages 101–115): E. J. Ambrose
Chapter eight mobile man made actions in Induction of Tissue Transformation (pages 116–130): Tuneo Yamada
Chapter nine the matter of the Chemical Nature of Embryonic Inducers (pages 131–147): Clifford Grobstein
Chapter 10 a few elements of the rules of Gene Expression within the Animal mobilephone (pages 148–162): G. P. Georgiev
Chapter eleven keep watch over of artificial job in the course of improvement (pages 163–177): Eugene Bell and F. Roy MacKintosh
Chapter 12 a few Experiments when it comes to the Homogeneity and association of the Ribosomal RNA Genes of Xenopus laevis (pages 178–195): Max Birnstiel
Chapter thirteen covering of Genes in Cytodifferentiation and Carcinogenesis (pages 196–207): John Paul
Chapter 14 components of development and upkeep of Tumours as geared up buildings in vitro (pages 208–218): Etienne Wolff and Emilienne Wolff
Chapter 15 The interplay of Tumour and Embryonic Tissue in vivo (pages 219–245): M. E. Whisson
Chapter sixteen Chairman's remaining comments (pages 246–247): Sir Alexander Haddow
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Extra info for Ciba Foundation Symposium - Cell Differentiation
He proposes that the lipids are structured in the bimolecular leaflet form of the Danielli model and that the specificity of the lipoprotein interaction is limited rather than high, The particulate subunit proposed is a distinct globular lipoprotein, that is, a spherical lipid micelle with an external protein coat. These subunits when aggregated are assumed to structure themselves in the form of a bimolecular leaflet of phospholipid with contiguous protein coats where thc protein resides in a mosaic pattern on the surface, possibly in the configuration of arrays of hexagonal spirals.
Kessel (1962)has presented evidence that these lamellae do result from budding, growth, pinching off and fusion of vesicles from the outer nuclear envelope. Whaley, Kephart and Mollenhauer (1964)have, on the other hand, reached different hypotheses about membrane development. Their studies on the primary root of Zea mays L. have led them to suggest that the endoplasmic reticulum originates from the ground substance of the cytoplasm and that the Golgi cisternae may result from components of this lamellar system.
A recent report by Haggis (1966)’ who claims that the bulk of DNA of high molecular weight is localized in the egg nucleus, adds to the present confusion. Very little is known about the mechanisms of DNA synthesis during oogenesis: the classical precursor for DNA synthesis, thymidine, is not incorporated to a measurable extent in the growing oocytes (in neither nucleus nor cytoplasm). It is quite possible that the bulk of cytoplasniic DNA (that is, the DNA of low molecular weight localized in the yolk platelets) is not synthesized by the oocytes themselves, but derives from the maternal blood-stream and the follicle cells (unpublished observations from our laboratory) : if so, it would be unlikely to play any important genetic role, unless it can cross several cell barriers without degradation.