Chemical Glycobiology by Randall L Halcomb, Peng George Wang, Xi Chen

By Randall L Halcomb, Peng George Wang, Xi Chen

content material: Preface; Chemical artificial tools for Chemical Glycobiology; 1. De Novo Synthesis in Carbohydrate Chemistry: From Furans to Monosaccharides and Oligosaccharides; 2. Chemical Syntheses of Hyaluronic Acid Oligosaccharides; three. man made Efforts in arrangements of elements of the Bacterial mobilephone Wall; four. New Glycosyl Thio-carboamino Peptides as New instruments for Glycobiology; Chemoenzymatic tools for Chemical Glycobiologu; five. Chemoenzymatic Synthesis of Sialosides and Their purposes; 6. Convergent Chemoenzymatic Synthesis of advanced N-Glycopeptides; Glycolipids; 7. Synthesis of Glycolipid Antigens; eight. Synthesis of Glycolipid Glycosphingolipids; Glycovaccines; nine. scientific final result of Breast and Ovarian melanoma sufferers handled after High-dose Chemotherapy and Autologous Stem mobile Rescue with Theratope (STn-KLH) melanoma Vaccine: Theratope (STn-KLH) melanoma Vaccine following Autologous Transplant; 10. Synthesis and overview of Anticancer Vaccine applicants, C-Glycoside Analogs of STn and PSA; instruments for Chemical Glycobiology; eleven. an automatic process for selecting Glycosylation and location variety in Glycoproteins; 12. Chemical techniques to Glycobiology; thirteen. automatic Solution-Phase Oligosaccharide Synthesis and Carbohydrate Microarrays: improvement of Fluorous-Based instruments for Glycomics; 14. Polypeptide-Based Glycopolymers for the examine of Multivalent Binding Events

Show description

Read or Download Chemical Glycobiology PDF

Similar organic books

Anionic Polymerization

This exhaustive reference textual content systematically introduces the elemental theories and experimental tools of anionic polymerization in addition to the synthesis, research, and features of anionically polymerized items.

Experimental Organic Chemistry: A Miniscale and Microscale Approach , Fifth Edition (Brooks Cole Laboratory Series for Organic Chemistry)

Delivering much more emphasis on inquiry-based studying, a brand new eco-friendly scan, and greater than a dozen new discovery experiments, this 5th version of Gilbert and Martin's confirmed EXPERIMENTAL natural CHEMISTRY includes strategies for either miniscale (also referred to as small scale) and microscale clients. The guide first offers an early concentrate on gear, checklist protecting, and defense within the laboratory, then walks scholars step-by-step throughout the laboratory concepts they should practice the book's experiments with self assurance.

Ciba Foundation Symposium 111 - Enzymes in Organic Synthesis

Content material: bankruptcy 1 Chairman's advent (pages 1–2): A. R. BattersbyChapter 2 An Illustrative instance of a Synthetically important Enzyme: Horse Liver Alcohol Dehydrogenase (pages 3–21): J. Bryan JonesChapter three Enzymic Synthesis of Labelled Chiral elements (pages 22–30): Alan R. BattersbyChapter four Enzyme?

Nitrile Oxides, Nitrones, and Nitronates in Organic Synthesis: Novel Strategies in Synthesis, Second Edition

A finished Systematization of present Novel facts in Nitrile Oxide Chemistry This ebook authoritatively covers systematic thoughts at the moment utilized in the education and usage of nitrile oxides, nitrones, and nitronates in natural synthesis. With contributions from top specialists within the box, it provides up to date details on: elements governing the steadiness of nitrile oxides, nitrones, and nitronates Syntheses, houses, and functions of reliable nitrile oxides, nitrones, and nitronates particular changes of risky nitrile oxides, nitrones, and nitronates within the absence of different reagents 1,3-dipolar cycloaddition and different addition reactions of nitrile oxides, nitrones, and nitronates With in-depth info on good and volatile nitrile oxides, Nitrile Oxides, Nitrones, and Nitronates in natural Synthesis, moment version is a useful reference for pros in natural chemistry and medicinal chemistry in academia, executive, and undefined, together with prescription drugs, effective chemical compounds, agrochemicals, and biotech.

Extra resources for Chemical Glycobiology

Example text

Biological studies indicated that sHA can have completely distinct novel properties from high molecular weight HA polymers, including stimulation of endothelial cell proliferation and migration (75), stimulation of angiogenesis (7), potentiation of the innate immune system (14-16), inhibition of tumor growth (17) and regulation of multi-drug resistance in cancer cells (18). Several cellular receptors for sHA have been identified. For example, Toll like receptor 4, which is a membrane bound receptor involved in initiation of innate immunity and prevention of early spread of pathogens, has been shown to be activated by sHA tetrasaccharides and hexasaccharides, rather than by the high molecular weight HA (14,15).

Org. Lett. 2002, 4, 4369-4372. For a related Rh system, see: Evans, P. ; Kennedy, L. J. Org. Lett. 2000, 2, 2213-2215. We have had great success at the preparation of optically pure furan alcohols from the Noyori reduction of the corresponding acylfuran, see: refs. ; Scott, J. ; O'Doherty, G. A. Tetrahedron Lett. 2004, 45, 1005-1009. ; Scott, J. ; O'Doherty, G. A. Tetrahedron Lett. 2004, 45, 6407-6411. ; O'Doherty, G. A. Org. Lett. 2006, 8, 1609-1612. Guppi, S. ; O'Doherty, G. A. Org. Lett. 2006, 8, 293-296.

Ed. 2001, 40, 3653-3655. For reduction of β-pyanones, the CeCl is necessary to avoid 1,4-reduction products. For Luche reduction, see: (a) Luche, J. L. J. Am. Chem. Soc. 1978, 100, 2226-2227. and ref. 13, 16, and 17. (a) King, J. ; Allbutt, A. D. Can. J. Chem. 1970, 48, 1754-1769. (b) Lowary, T. ; Hindsgaul, O. Carbohydr. Res. 1994, 251, 33-67. edu 2 The increasing recognition of important biological functions of hyaluronic acid oligosaccharides (sHA) has led to developments of new methodologies for sHA syntheses.

Download PDF sample

Rated 5.00 of 5 – based on 36 votes