Compiler design issues for embedded processors by Leupers R.

By Leupers R.

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Polymorphism of Pharmaceutical Solids. Marcel Dekker, New York, 1999. Brittain HG and Grant DJW. Effects of Polymorphism and Solid-State Solvation on Solubility and Dissolution Rate. ), Polymorphism of Pharmaceutical Solids. Marcel Dekker, New York, 1999, pp. 279–330. Davis SS, Higuchi T, and Rytting JH. Determination of Thermodynamics of Functional Groups in Solutions of Drug Molecules. ), Advances in Pharmaceutical Sciences, Vol. 4. Academic Press, New York, 1974, pp. 73–261. Eyjolfsson R. Nitrofurantoin: Particle Size and Dissolution.

Under those conditions, both γH + and γA − will be approximately equal to one, and then one can approximate the thermodynamic equilibrium constant, K, by the concentration-based ionization constant, KA . A strong acid is defined as a substance that reacts completely with water, so that the acid ionization constant defined in equation (21) or (22) is effectively infinite. This situation can only be achieved if the conjugate base of the strong acid is very weak. A weak acid will be characterized by an acid ionization constant that is considerably less than unity, so that the position of equilibrium in the reaction represented in equation (20) favors the existence of un-ionized free acid.

Hancock BC and Zografi G. Characteristics and Significance of the Amorphous State in Pharmaceutical Systems. J Pharm Sci 1996; 86: 1–12. Hansen C and Beerbower A. Solubility Parameters. ), KirkOthmer Encyclopedia of Chemical Technology, 2nd ed. Supplement Volume, John Wiley & Sons, New York, 1971, pp. 889–910. Higuchi T. Solubility. ), Pharmaceutical Compounding and Dispensing, Lippincott Philadelphia, PA, 1949, pp. 176–177. Higuchi WI, Rowe EL, and Hiestand EN. Dissolution Rates of Finely Divided Drug Powders.

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