By Anne J. Ridley (auth.), Professor Dr. Philippe Jeanteur (eds.)
The inner constitution of a cellphone will be suffering from signs within the type of small molecules open air the telephone. those alterations can then regulate the form or adhesiveness of the mobile. This quantity facilities fairly on one relations of mobile proteins which transmit those indications, the Rho Ras-like GTPases, and examines their position in basic mobile techniques and improvement. additionally mentioned are their roles in melanoma formation and microbial pathogenesis.
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Additional info for Cytoskeleton and Small G Proteins
Moesin is phosphorylated at Thr 558 in thrombin-activated platelets (Nakamura et al. 1995). After further analysis using a phosphorylation site-specific antibody, it is speculated that the phosphorylation at Thr 558 of Regulation of Cytoskeleton and Cell Adhesion by Rho Targets 31 Table 1. D. MBS Adducin ERM (ezrin, radixin, moesin) Intermediate filament (GFAP, vimentin) + moesin is required for the stable interaction of moesin with actin at filopodia (Nakamura et al. 1996). Rho-kinase phosphorylates the ERM family (Matsui et al.
The complete human cDNAs for Rnd1, Rnd2, and a third closely related member, Rnd3 were subsequently obtained (Fig. 1). Rnd3 is identical to the recently described RhoE (Foster et al. 1996), except that the published RhoE sequence lacks 15 N-terminal amino acids. The first five amino acids of this Nter sequence (MKERRA) of Rnd3 are identical to those of Rndl. In Rnd1 this sequence is essential for the intracellular localization and activity of the protein (Nobes et al. 1998). Rnd proteins share 54-63% identity pairwise, around 45-49% identity with RhoA and slightly less identity with other Rho family members such as Rac or Cdc42, thus the three Rnd proteins form a new branch of the Rho family.
Biochemistry 24: 1160-1164 Nishiki T, Narumiya S, Morii N, Yamamoto M, Fujiwara M, Kamata Y, Sakaguchi G, Kozaki S (1990) ADP-ribosylation of the rholrac proteins induces growth inhibition, neurite outgrowth and acetylcholine esterase in cultured PC-12 cells. Biochem Biophys Res Commun 167:265272 Nishiyama T, Sasaki T, Takaishi K, Kato M, Yaku H, Araki K, Matsuura Y, Takai Y (1994) rae p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.